About Me

Dr Alexandra B Milsom

I’m an experienced scientist with a passion for science communication. I have a background in pharmacology and physiology, spanning ten years of research experience across the UK and USA.

As a Science, Technology, Engineering and Mathematics Network (STEM NET) ambassador, judge for the London Science and Engineering Competition, science advisor to theatre groups and artists, and science director of a theatre company, my enthusiasm for science is infectious.

I’m a firm advocate for the power of education through the fusion of art and science and have worked with a wide range of cultural organisations and individuals in funding, creating and delivering challenging and effective live events for a broad range of audiences.

Projects

Publications

Research Papers

  • Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S, Yousuf M, Benjamin N, Webb AJ, Caulfield MJ, Hobbs AJ, Ahluwalia A. Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential. Hypertension. 2013 May;61(5):1091-102.
  • Baliga RS, Milsom AB, Ghosh SM, Trinder SL, Macallister RJ, Ahluwalia A, Hobbs AJ. Dietary Nitrate Ameliorates Pulmonary Hypertension: Cytoprotective Role for Endothelial Nitric Oxide Synthase and Xanthine Oxidoreductase. Circulation. 2012 Jun 12;125(23):2922-32.
  • Milsom AB, Fernandez BO, Garcia-Saura MF, Rodriguez J, Feelisch M. Contributions of Nitric Oxide Synthases, Dietary Nitrite/Nitrate, and Other Sources to the Formation of NO Signaling Products. Antioxid Redox Signal. 2012 Aug 1;17(3):422-32.
  • Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ, Webb AJ, Ahluwalia A. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension. 2010; 56(3):e37-9.
  • Yamashiro K, Milsom AB, Duchene J, Panayiotou C, Urabe T, Hattori N, Ahluwalia A. Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice. J Cereb Blood Flow Metab. 2010; 30(8):1494-503.
  • Saijo F, Milsom AB, Bryan NS, Bauer SM, Vowinkel T, Ivanovic M, Andry C, Granger N, Rodriguez J, Feelisch M. On the Dynamics of Nitrite, Nitrate, and Other Biomarkers of Nitric Oxide Production in Inflammatory Bowel Disease. Nitric Oxide. 2010; 22(2): 155-67.
  • Milsom AB, Patel NS, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ, Cuzzocrea S, Hobbs AJ, Thiemermann C, Ahluwalia A. Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice. Nitric Oxide. 2010; 22(2): 141-148.
  • Ingram TE, Pinder AG, Milsom AB, Rogers SC, Thomas DE, James PE. Blood vessel specific vaso-activity to nitrite under normoxic and hypoxic conditions. Adv Exp Med Biol. 2009; 645: 21-25.
  • Milsom AB, Webb AJ, Rathod KS, Chu WL, Qureshi S, Lovell MJ, Lecomte FMJ, Perrett D, Raimondo C, Khoshbin E, Ahmed Z, Uppal R, Benjamin N, Hobbs AJ, Ahluwalia A. Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase. Circulation Research. 2008; 103(9):957-U114.
  • Maher AR, Milsom AB, Gunaruwan P, Abozguia K, Ahmed I, Weaver RA, Thomas P, Ashrafian H, Born GVR, James PE, Frenneaux MP. Hypoxic modulation of exogenous nitrite-induced vasodilation in humans. Circulation. 2008; 117(5): 670-677.
  • Zamora R, Bryan NS, Boyle P, Wong C, Milsom AB, Jaffe R, Feelisch M, Ford HR. Nitrosative stress in an animal model of necrotizing enterocolitis. Free Radical Biology and Medicine. 2005; 39(11): 1428-37.
  • Bryan NS, Fernandez BO, Garcia-Saura MF, Bauer SM, Milsom AB, Rassaf T, Rodriguez J, Feelisch M. Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nature Chemical Biology. 2005; 1: 290-297.
  • James PE, Lang D, Tuffnell-Barret T, Milsom AB, Frenneaux MP. Red blood cell-mediated hypoxic vasodilatation: a balanced physiological viewpoint.Circulation Research. 2004; 95(2): e8-9.
  • James PE, Lang D, Tuffnell-Barret T, Milsom AB, Frenneaux MP. Vasorelaxation by red blood cells and impairment in diabetes: reduced nitric oxide and oxygen delivery by glycatedhemoglobin. Circulation Research. 2004; 94(7): 976-83.
  • Milsom AB, Jones CJ, Goodfellow J, Frenneaux MP, Peters JR, James PE. Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus. Diabetologia. 2002; 45(11): 1515-1522.

 

Reviews and Commentaries

  • Milsom AB &Ahluwalia A. Nitrite; a ‘reductionist’ approach to cardiovascular disease. The Bulletin. 2010; 23(1):4-9.
  • Milsom AB & Webb AJ. Eat Your Beets! Pharmacology Matters 2009 Apr;2(1):4-5

Book Chapters

  • Rogers SC & Milsom AB. 2009. The Biological Chemistry of Nitric Oxide in the Vascular System in Perspectives on NO in Physiology and Pathology. In Richardson VJ & Wallace AV (Ed), Perspectives on NO in Physiology and Pathology. India: Transworld Research Network 2009. P25-49.